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Wednesday, October 3, 2012

2 lb pail # Protazil 2 lb pail

Protazil 2 lb pail 
Protazil diclazuril1.56% is an alfalfa-based antiprotozoal pellet indicated for the treatment of equine protozoal myeloencephalitis EPM caused by S. neurona in horses. It is labeled for a dosage rate of 1 mg/kg for 28 consecutive days. For use in horses only.

Weight Range of Horse lb
mLs of Pellets
275 - 524
20
525 - 774
30
775 - 1024
40
1025 - 1274
50
1275 - 1524
60
1525 - 1774
70
1775 - 2074
80
ADVERSE REACTIONS
There were no adverse effects noted in the field study which could be ascribed to diclazuril. To report suspected adverse reactions, to obtain a MSDS, or for technical assistance call 1-800-224-5318.
CLINICAL PHARMACOLOGY
The effectiveness of diclazuril in inhibiting merozoite production of Sarcocystis neurona and S. falcatula in bovine turbinate cell cultures was studied by Lindsay and Dubey 2000.1 Diclazuril inhibited merozoite production by more than 80% in cultures of S. neurona or S. falcatula treated with 0.1 ng/mL diclazuril and greater than 95% inhibition of merozoite production IC95 was observed when infected cultures were treated with 1.0 ng/mL diclazuril. The clinical relevance of the in vitro cell culture data has not been determined.

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