Protazil diclazuril1.56% is an alfalfa-based antiprotozoal pellet indicated for the treatment of equine protozoal myeloencephalitis EPM caused by S. neurona in horses. It is labeled for a dosage rate of 1 mg/kg for 28 consecutive days. For use in horses only.
Weight Range of Horse lb
|
mLs of Pellets
|
275 - 524
|
20
|
525 - 774
|
30
|
775 - 1024
|
40
|
1025 - 1274
|
50
|
1275 - 1524
|
60
|
1525 - 1774
|
70
|
1775 - 2074
|
80
|
ADVERSE REACTIONS
There were no adverse effects noted in the field study
which could be ascribed to diclazuril. To report suspected adverse
reactions, to obtain a MSDS, or for technical assistance call 1-800-224-5318.
CLINICAL PHARMACOLOGY
The effectiveness of diclazuril in inhibiting merozoite production of Sarcocystis neurona and S. falcatula in bovine turbinate cell cultures was studied by Lindsay and Dubey 2000.1 Diclazuril inhibited merozoite production by more than 80% in cultures of S. neurona or S. falcatula treated with 0.1 ng/mL diclazuril and greater than 95% inhibition of merozoite production IC95
was observed when infected cultures were treated with 1.0 ng/mL
diclazuril. The clinical relevance of the in vitro cell culture data has
not been determined.
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